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Search Results for " angiotensin 1-7 "

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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7339	Angiotensin (1-7) Ang-(1-7),Angiotensin 1-7,ASP-ARG-VAL-TYR-ILE-HIS-PRO	RAAS; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) 是肾素-血管紧张素系统中的内源性七肽。Angiotensin 1-7在心肌细胞中具有抗炎和抗纤维化活性，因此具有心脏保护作用。它能抑制血管紧张素转换酶和释放一氧化氮，是激肽诱导的血管舒张的局部协同调节剂。它阻断 Ang II 诱导的平滑肌细胞增殖和肥大，并显示对内皮的抗血管生成和生长抑制作用。它显示出抗炎活性。
T22574L	Angiotensin 1/2 (5-7) acetate	RAAS	Endocrinology/Hormones
	Angiotensin 1/2 (5-7) acetate 是一种具有 H2N-Ile-His-Pro-OH 序列的肽。血管紧张素是一种寡肽，是一种激素和一种强大的双肽原。它来源于前体分子血管紧张素原，一种在肝脏中产生的血清球蛋白。它在肾素-血管紧张素系统中起重要作用。
T37495	Angiotensin (1-7) (acetate)
	Angiotensin 1-7 (Ang-(1-7)) acetate 是RAS中的一种内源性七肽，具备心脏保护作用，主要表现为对心肌细胞的抗炎与抗纤维化活性。该化合物能抑制纯化的犬ACE活性（IC50=0.65 μM），通过降低ACE活性并促进一氧化氮释放，作为血管舒张调节的局部协同因子。此外，Angiotensin 1-7 acetate 可阻止血管紧张素Ⅱ诱发的平滑肌细胞增殖和肥大，同时对内皮细胞表现出抗血管生成和生长抑制作用。
T22575	Angiotensin Fragment 1-7 (acetate)	Others	Others
	Angiotensin Fragment 1-7 is a type 1 angiotensin II receptor agonist. In the renin-angiotensin system, angiotensin I is cleaved by the angiotensin-converting enzyme to form angiotensin II, which has effects on fluid and electrolyte, as well as homeostasis
T22574	Angiotensin 1/2 (5-7)	Others	Others
	Angiotensin 1/2 (5-7) is a peptide with the sequence H2N-Ile-His-Pro-OH. Angiotensin is an oligopeptide and is a hormone and a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays a
T22573	Angiotensin 1/2 (2-7)	Others	Others
	Angiotensin I/II (2-7) is a peptide that contains the amino acids 2-7 and is converted from Angiotensin I/II peptide. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. Angiotensin also stimulates th
T22572	Angiotensin 1/2 (1-7) amide	Others	Others
	Angiotensin I/II (1-7) amide is a peptide analog to angiotensin II that is used as a vasopressor in the treatment of certain types of shock and circulatory collapse. Angiotensin I/II amide is an amide derivative of angiotensin II that is a powerful vasoco
T37496	Alamandine
	Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effe...
T7616L	A 779 TFA(159432-28-7 free base) A 779 3TFA(159432-28-7(free base))	RAAS	Endocrinology/Hormones
	A 779 TFA 是血管紧张素-(1-7) 受体的有效拮抗剂。
TQ0057	AVE 0991	Others	Others
	AVE 0991 是血管紧张素-(1-7) [Ang-(1-7)] 的非肽类似物，是一种具有口服活性的 Mas 激动剂，对 [125I]-Ang-(1-7) 结合到牛主动脉内皮细胞膜有抑制作用，通过增强自噬来抑制星形胶质细胞介导的阿尔茨海默病神经炎症。
T27229	E-4177 E4177
	E-4177 is an angiotensin type 1 receptor antagonist. In rat adrenal cortex and liver, E4177 competitively inhibited the specific binding of 125I-[Sar1,Ile8]Ang II, with IC50 being (5.2 +/- 1.0) x 10(-8) M for the adrenal cortex and (1.2 +/- 0.3) x 10(-7)
T26554	Aclerastide DSC-127,DSC 127,NorLeu-3-A(1-7),DSC127,NorLeu-3A(1-7)
	Aclerastide is an angiotensin receptor agonist. Administration of Aclerastide reduced fibrosis and scarring in the healing wounds. This action was more pronounced with longer administration of the peptide after injury. The action of this peptide was block

化合物

Angiotensin (1-7)

Cat.No: T7339

Synonym: Ang-(1-7),Angiotensin 1-7,ASP-ARG-VAL-TYR-ILE-HIS-PRO

Target: RAAS, Endogenous Metabolite

Angiotensin 1/2 (5-7) acetate

Cat.No: T22574L

Target: RAAS

Angiotensin (1-7) (acetate)

Cat.No: T37495

Angiotensin Fragment 1-7 (acetate)

Cat.No: T22575

Target: Others

Angiotensin 1/2 (5-7)

Cat.No: T22574

Target: Others

Angiotensin 1/2 (2-7)

Cat.No: T22573

Target: Others

Angiotensin 1/2 (1-7) amide

Cat.No: T22572

Target: Others

Cat.No: T37496

A 779 TFA(159432-28-7 free base)

Cat.No: T7616L

Synonym: A 779 3TFA(159432-28-7(free base))

Target: RAAS

Cat.No: TQ0057

Target: Others

Cat.No: T27229

Synonym: E4177

Cat.No: T26554

Synonym: DSC-127,DSC 127,NorLeu-3-A(1-7),DSC127,NorLeu-3A(1-7)

Cat. No.	Product Name	Target	Signaling Pathways
T6S0657	Isorhynchophylline IsoRhy,异钩藤碱,Isorhyncophylline,Isorhychophylline,7-Isorhyncophylline	Others	Others
	Isorhynchophylline (7-Isorhyncophylline) 是一种分离自钩藤中的生物碱类化合物，具有舒张血管、降血压、保护神经免于局部缺血造成损伤的作用。

天然产物

Isorhynchophylline

Cat.No: T6S0657

Synonym: IsoRhy,异钩藤碱,Isorhyncophylline,Isorhychophylline,7-Isorhyncophylline

Target: Others

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